Revolutionizing Arthritis Care with Artificial Intelligence:A Comprehensive Review of Diagnostic, Prognostic, and Treatment Innovations
Keywords:
Arthritis;, Radiology, Artificial Intelligence, TreatmentAbstract
Arthritis, a leading cause of disability worldwide, predominantly manifests as osteoarthritis (OA) and rheumatoid arthritis (RA). Traditional diagnostic methods for arthritis, including clinical assessments and radiographic imaging, face significant limitations such as subjectivity and late-stage detection. Artificial Intelligence (AI), encompassing machine learning (ML) and deep learning (DL) techniques has emerged as a transformative tool in healthcare, offering potential solutions to these challenges. AI can process vast datasets to identify patterns that elude human observation, thus enhancing diagnostic accuracy, predicting disease progression, and optimizing treatment strategies in arthritis care. Recent studies have demonstrated AI’s capability to improve the early detection of OA and RA through advanced imaging analysis. AI models, particularly convolutional neural networks (CNNs), have effectively identified early signs of arthritis, such as joint space narrowing and synovial inflammation, with greater precision than conventional methods. Furthermore, AI’s predictive power extends to assessing the progression of arthritis and tailoring personalized treatment plans, significantly enhancing patient outcomes. This review provides a comprehensive overview of AI applications in arthritis, focusing on diagnostic advancements, prognostic models, and treatment response predictions. It highlights the integration of AI into various imaging modalities, the incorporation of genetic and molecular data, and the use of patient-reported outcomes and wearable technology in AI models. The review also addresses the impact of the COVID-19 pandemic on arthritis management, exploring how AI has been utilized to study the intersection between COVID-19 and arthritis. While the potential of AI in revolutionizing arthritis care is evident, challenges such as data diversity, model interpretability, and ethical considerations must be addressed to fully realize its benefits. As AI technology continues to evolve, it is poised to play an increasingly critical role in the management of arthritis, offering new avenues for early detection, personalized treatment, and improved patient care.
References
[1] Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2197–223.
[2] Murphy L, Helmick CG. The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs. 2012;112(3 Suppl 1):S13–9.
[3] Mahmoudiandehkordi S, Yeganegi M, Shomalzadeh M, Ghasemi Y, Kalatehjari M. Enhancing IVF Success: Deep Learning for Accurate Day 3 and Day 5 Embryo Detection from Microscopic Images. International Journal of Applied Data Science in Engineering and Health. 2024 Aug 14;1(1):18-25.
[4] Abbasi H, Orouskhani M, Asgari S, Zadeh SS. Automatic brain ischemic stroke segmentation with deep learning: A review. Neuroscience Informatics. 2023 Sep 22:100145.
[5] Kharaji M, Abbasi H, Orouskhani Y, Shomalzadeh M, Kazemi F, Orouskhani M. Brain Tumor Segmentation with Advanced nnU-Net: Pediatrics and Adults Tumors. Neuroscience Informatics. 2024 Feb 22:100156.
[6] Akhoondinasab M, Shafaei Y, Rahmani A, Keshavarz H. A Machine Learning-Based Model for Breast Volume Prediction Using Preoperative Anthropometric Measurements. Aesthetic Plastic Surgery. 2024 Feb;48(3):243-9.
[7] Weinstein AM, Rome BN, Reichmann WM, Collins JE, Burbine SA, Thornhill TS, et al. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am. 2013;95(5):385–92.
[8] Center ME-bP. Total knee replacement. Minneapolis: Agency for Healthcare and Research Quality; 2003.
[9] Azhideh A, Pooyan A, Alipour E, Haseli S, Hosseini N, Chalian M. The Role of Artificial Intelligence in Osteoarthritis. InSeminars in Roentgenology 2024 Jul 30. WB Saunders.
[10] Dell’Isola A, Allan R, Smith SL, Marreiros SS, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016;17(1):425.
[11] Waarsing JH, Bierma-Zeinstra SM, Weinans H. Distinct subtypes of knee osteoarthritis: data from the Osteoarthritis Initiative. Rheumatology (Oxford). 2015;54(9):1650–8.
[12] Deveza LA, Melo L, Yamato TP, Mills K, Ravi V, Hunter DJ. Knee osteoarthritis phenotypes and their relevance for outcomes: a systematic review. Osteoarthritis Cartilage. 2017;25(12):1926–41.
[13] Roddy E, Doherty M. Changing life-styles and osteoarthri- tis: what is the evidence? Best Pract Res Clin Rheumatol. 2006;20(1):81–97.
[14] Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, et al. Risk factors for the incidence and progres- sion of radiographic knee osteoarthritis. Arthritis Rheum. 2000;43(5):995–1000.
[15] Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castro- giovanni P, Mobasheri A. Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and pro- gression. Int J Mol Sci. 2015;16(3):6093–112.
[16] Alipour E, Chalian M, Pooyan A, Azhideh A, Shomal Zadeh F, Jahanian H. Automatic MRI–based rotator cuff muscle segmentation using U-Nets. Skeletal Radiology. 2024 Mar;53(3):537-45.
[17] Baum T, Joseph GB, Arulanandan A, Nardo L, Virayavanich W, Carballido-Gamio J, et al. Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative. Arthritis Care Res. 2012;64(2):248–55.
[18] Joseph GB, Baum T, Alizai H, Carballido-Gamio J, Nardo L, Virayavanich W, et al. Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years–data from the Osteoarthritis Initiative. Osteoarthr Cartil. 2012;20(7):727–35.
[19] Cabitza F, Locoro A, Banfi G. Machine learning in orthopedics: a literature review. Front Bioeng Biotechnol. 2018;6:75.
[20] Kokkotis C, Moustakidis S, Papageorgiou E, Giakas G, Tsaopou- los DE. Machine learning in knee osteoarthritis: a review. Osteo- arthritis and Cartilage Open. 2020;2(3):100069.
[21] Hirschmann A, Cyriac J, Stieltjes B, Kober T, Richiardi J, Omoumi P. Artificial intelligence in musculoskeletal imaging: review of current literature, challenges, and trends. Semin Mus- culoskelet Radiol. 2019;23(3):304–11.
[22] Joseph GB, McCulloch CE, Nevitt MC, Neumann J, Gersing AS, Kretzschmar M, et al. Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: data from the osteoarthritis initiative. J Magn Reson Imag- ing. 2018;47(6):1517–26.
[23] Norman B, Pedoia V, Noworolski A, Link TM, Majumdar S. Applying densely connected convolutional neural networks for staging osteoarthritis severity from plain radiographs. J Digit Imaging. 2019;32(3):471–7.
[24] Furche T, Gottlob G, Libkin L, Orsi G, Paton NW. Data wran- gling for big data: challenges and opportunities. InEDBT. 2016;16:473–8.
[25] Rahmn AU. What is data cleaning? How to process data for analytics and machine learning modeling? : toward data sci- ence; 2019 Available from: https://towardsdatascience.com/what-is-data-cleaning-how-to-process-data-for-analytics-and-machine-learning-modeling-c2afcf4fbf45.
[26] Ashrafi F, Zali A, Ommi D, Salari M, Fatemi A, Arab-Ahmadi M, Behnam B, Azhideh A, Vahidi M, Yousefi-Asl M, Jalili Khoshnood R. COVID-19-related strokes in adults below 55 years of age: a case series. Neurological Sciences. 2020 Aug;41:1985-9.
[27] Azhideh A. COVID-19 neurological manifestations. International Clinical Neuroscience Journal. 2020 Mar 10;7(2):54-.
[28] Afrazeh F, Ghasemi Y, Abbasi H, Rostamian S, Shomalzadeh M. Neurological Findings Associated with Neuroimaging in COVID-19 Patients: A Systematic Review. International Research in Medical and Health Sciences. 2024 Jul 30;7(3):1-5.
[29] Radpour A, Bahrami-Motlagh H, Taaghi MT, Sedaghat A, Karimi MA, Hekmatnia A, Haghighatkhah HR, Sanei-Taheri M, Arab-Ahmadi M, Azhideh A. COVID-19 evaluation by low-dose high resolution CT scans protocol. Academic radiology. 2020 Jun;27(6):901.
[30] Khoshnood RJ, Ommi D, Zali A, Ashrafi F, Vahidi M, Azhide A, Shirini D, Sanadgol G, Khave LJ, Nohesara S, Nematollahi S. Epidemiological characteristics, clinical features, and outcome of COVID-19 patients in northern Tehran, Iran; a cross-sectional study. Frontiers in Emergency Medicine. 2021;5(1):e11-.
[31] Sedaghat A, Gity M, Radpour A, Karimi MA, Haghighatkhah HR, Keshavarz E, Hekmatnia A, Arab-Ahmadi M, Sanei-Taheri M, Azhideh A. COVID-19 protection guidelines in outpatient medical imaging centers. Academic radiology. 2020 Jun;27(6):904.
[32] Abrishami A, Eslami V, Arab-Ahmadi M, Alahyari S, Azhideh A, Sanei-Taheri M. Prognostic value of inflammatory biomarkers for predicting the extent of lung involvement and final clinical outcome in patients with COVID-19. Journal of Research in Medical Sciences. 2021 Jan 1;26(1):115.
[33] Azhideh A, Menbari-Oskouie I, Yousefi-Asl M. Neurological manifestation of COVID-19: a literature review. Int Clin Neurosci J. 2020 Jan 1;7(4):164-70.
[34] Singh A, Thakur N, Sharma A, editors. A review of supervised machine learning algorithms. 2016 3rd International Confer- ence on Computing for Sustainable Global Development (INDI- ACom); 2016 16–18 March 2016.
[35] Kherif F, Latypova A. Chapter 12 - Principal component analy- sis. In: Mechelli A, Vieira S, editors. Machine Learning. Aca- demic Press; 2020. p. 209–25.
[36] Kokkotis C, Moustakidis S, Papageorgiou E, Giakas G, Tsao- poulos DE. Machine learning in knee osteoarthritis: a review. Osteoarthr Cartil Open. 2020;2(3):100069.
[37] Grootendorst M. Validating your machine learning model, going beyond k-fold cross-validation 2019 Available from: https:// towardsdatascience.com/validating-your-machine-learning- model-25b4c8643fb7.
[38] Narkhede S. Understanding AUC-ROC curve. Towards data science. 2018;26. https://towardsdatascience.com/understand ing-auc-roc-curve-68b2303cc9c5.
[39] Maroco J, Silva D, Rodrigues A, Guerreiro M, Santana I, de Mendonça A. Data mining methods in the prediction of demen- tia: a real-data comparison of the accuracy, sensitivity and specificity of linear discriminant analysis, logistic regression, neural networks, support vector machines, classification trees and random forests. BMC Res Notes. 2011;4(1):299.
[40] Powers DM. Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation. arXiv preprint arXiv:201016061. 2020.
[41] Ping Shung K. Accuracy, precision, recall or F1? https://towar dsdatascience.com/accuracy-precision-recall-or-f1-331fb37c5c b9 [Internet]. 2018; 2021.
[42] Dice LR. Measures of the amount of ecologic association between species. Ecology. 1945;26(3):297–302.
[43] Laber EB, Murphy SA, editors. Small sample inference for gen- eralization error in classification using the CUD bound. Uncer- tainty in artificial intelligence: proceedings of the conference Conference on Uncertainty in Artificial Intelligence; 2008: NIH Public Access.
[44] Stead WW. Clinical implications and challenges of artificial intelligence and deep learning. JAMA. 2018;320(11):1107–8.
[45] Kerkhof HJ, Bierma-Zeinstra SM, Arden NK, Metrustry S, Castano-Betancourt M, Hart DJ, et al. Prediction model for knee osteoarthritis incidence, including clinical, genetic and bio- chemical risk factors. Ann Rheum Dis. 2014;73(12):2116–21.